Ltd (SAJA) Riyadh Pharma (Medical and Cosmetic Products Company Ltd.) Do not use if you have ever had an allergic reaction to dapoxetine hydrochloride or any of the ingredients listed at the end of the CMI.
| Advice | Rationale | Additional Notes |
|---|---|---|
| Avoid alcohol | Enhances side effects, impairs judgment | For optimal safety |
| Report adverse effects | Ensures proper management | Contact healthcare provider swiftly |
| Do not double dose | Risk of overdose and side effects | Follow prescribed instructions |
| Use only as directed | Prevent misuse or dependence | Not for daily use or recreational use |
There are a number of circumstances in which a person should not take this medicine or may need to use caution.
It is important to understand if these apply to you before taking PRILIGY.
Vardenafil has been clinically appeared to improve erectile capacity, even in men who had other wellbeing factors, similar to elevated cholesterol, hypertension, or diabetes. Dapoxetine hydrochloride was initially an upper and one of the symptoms of a few antidepressants is hindered discharge (a powerlessness to achieve climax), failure to continue an erection as well as feebleness. Extra Super Zhewitra is the latest medicine for the treatment of erectile dysfunction and premature ejaculation. I am Interested Request a call back I am Interested Request a call back I am Interested Request a call back I am Interested Request a call back I am Interested Request a call back Much attention is paid to erectile dysfunction, but did you know there are other aspects of the male sexual response cycle that need attention as well? Specifically, rapid or premature ejaculation, delayed ejaculation, and arousal deficiency.
One in three men experiences rapid ejaculation and an estimated 1-4% of men experience delayed ejaculation. [1][2] These conditions are underserved and undertreated but that can change. Many providers who are experts in male reproductive health specialize in combination therapies that are designed to take treatment beyond ED and address co-conditions like premature and delayed ejaculation. [1][2] Integrative solutions are key in helping men’s overall vitality. PDE5, or phosphodiesterase type 5, is an enzyme in the body that affects smooth muscle contraction.
So, when PDE5 is inhibited, muscles may remain contracted. Though FDA-approved treatments for erectile dysfunction exist, there are no commercially available options for rapid ejaculation or delayed ejaculation. For patient-specific options, providers may combine a unique variety of ingredients with some PDE5 inhibitors when they formulate treatments for conditions related to sexual health and overall quality of life. Urologists and men’s health practitioners have long used compounding pharmacies to source these options. Prescribers using emerging therapies for male sexual health may often combine one or more of the following ingredients with PDE5 inhibitors: Prescribers may seek compounded PDE5 inhibitor medications because they are offered in a range of strengths, combinations and alternative dosage forms. Talk to your doctor or pharmacist if you have any concerns about taking this medicine.
| Interaction Partner | Effect on Priligy | Clinical Implication | Notes |
|---|---|---|---|
| CYP3A4 inhibitors | Increased levels | Higher risk of side effects | Dose adjustment needed |
| Other SSRIs | Serotonin syndrome | Severe, potentially life-threatening | Avoid concurrent use |
| Alcohol | Increased dizziness | Enhance side effects | Limit or avoid consumption |
| QT-prolonging drugs | Additive effect | Risk of arrhythmia | Monitor cardiac status |
The recommended dose is one tablet (30 mg) taken when you need it, about 1 to 3 hours before sexual activity.
| Product | Dosage | Quantity + Bonus | Price | |
|---|---|---|---|---|
| Kamagra Oral Jelly | 100 mg | 110 + 9 Sachets | 334.87€ 318.92€ | |
| Priligy Generic Dapoxetine | 60mg | 20 + 4 Pills | 77.31€ 73.63€ | |
| Priligy Generic Dapoxetine | 60mg | 30 + 6 Pills | 106.65€ 101.57€ | |
| Priligy Generic Dapoxetine | 60mg | 180 + 10 Pills | 494.76€ 471.20€ | |
| Kamagra Effervescent Tablets | 100 mg | 28 Pills | 90.83€ 86.50€ | |
| Priligy Generic Dapoxetine | 60mg | 10 Pills | 47.63€ 45.36€ | |
| Priligy Generic Dapoxetine | 60mg | 60 + 8 Pills | 183.06€ 174.34€ | |
| Cialis Generic | 5mg | 90 + 6 Pills | 115.91€ 110.39€ | |
| Priligy Generic Dapoxetine | 60mg | 90 + 10 Pills | 265.64€ 252.99€ | |
| Priligy Generic Dapoxetine | 60mg | 120 + 10 Pills | 341.26€ 325.01€ |
Do not take more than one tablet in a 24 hour period.
Withdrawal Effects: Abrupt discontinuation of chronically administered SSRIs used to treat chronic depressive disorders has been reported to result in the following symptoms: Dysphoric mood, irritability, agitation, dizziness, sensory disturbances (eg, paresthesias, electric shock sensations), anxiety, confusion, headache, lethargy, emotional lability, insomnia and hypomania. Risk of serotonergic-associated effects w/ serotonergic medicinal/herbal products (including L-tryptophan, triptans, tramadol, linezolid, SSRIs, SNRIs, lithium & St. John's wort prep). Possible reduction of clearance w/ CYP2D6, CYP3A4 & flavin monooxygenase 1 inhibitors. Possible reduced orthostatic tolerance w/ PDE-5 inhibitors & ?-adrenergic receptor antagonists.
Increases plasma conc of desipramine & other drugs metabolized by CYP2D6. Side effects of Dapoxetine : Syncope characterized as loss of consciousness has been reported.The majority of cases occurred during the first 3 hrs after dosing, after the 1st dose or associated with study-related procedures in the clinic setting (eg, blood draw and orthostatic maneuvers and blood pressure measurements). Orthostatic hypotension has been reported in clinical trials. The most common adverse drug reactions (5%) reported during clinical trials were headache, dizziness, nausea, diarrhea, insomnia and fatigue. The most common events leading to discontinuation were nausea and dizziness. It is not intended for continuous daily use.
Swallow the tablet whole with at least one full glass of water.
Empower Pharmacy offers 22 different PDE5 inhibitor options ranging from capsules and oral disintegrating tablets (ODTs) to troches, many of which are listed below. Providers who already work with Empower may talk to their Clinic Liaison if they are interested in these or other options. Providers who are interested in partnering with Empower may contact us about these products and anything else we can offer their practices and patients. Expert providers may turn to custom combination therapies to potentially address patients’ multiple issues, including ED. PRILIGY Film-coated Tablet is used for: Premature ejaculation Oral Premature Ejaculation Adult: 18-64 yr Initially, 30 mg approx 1-3 hr before sexual activity, subsequent doses adjusted according to response.
Dose should not be taken more than once in 24 hr. Review treatment after 4 wk (6 doses) and at least 6 mthly thereafter. Patients with Renal Impairment: No dose adjustment is required but caution is advised in patients with mild or moderate renal impairment. Dapoxetine is not recommended for use in the patients with severe renal impairment. May be taken with or without food.
Swallow tab whole & take w/ a full glass of water. Known hypersensitivity to dapoxetine HCl or to any of the excipients. Patients with significant pathological cardiac conditions [eg, heart failure (NYHA class II-IV), conduction abnormalities (2nd- or 3rd-degree AV block or sick sinus syndrome) not treated with a permanent pacemaker, significant ischemic heart disease or significant valvular disease]. Concomitant treatment with monoamine oxidase inhibitors (MAOIs), or within 14 days of discontinuing treatment with a MAOI. Similarly, a MAOI should not be administered within 7 days after Dapoxetine has been discontinued. PRILIGY can be taken with or without food.
Concomitant treatment with thioridazine, or within 14 days of discontinuing treatment with thioridazine. Similarly, thioridazine should not be administered within 7 days after Dapoxetine has been discontinued. Concomitant treatment with serotonin re-uptake inhibitors [selective serotonin re-uptake inhibitors (SSRIs), serotonin-norepinephrine re-uptake inhibitors (SNRIs), tricyclic antidepressants (TCAs)] or other medicinal/herbal products with serotonergic effects or within 14 days of discontinuing treatment with these medicinal/herbal products. Similarly these medicinal/herbal products should not be administered within 7 days after Dapoxetine has been discontinued. General: Dapoxetine is only indicated in men with PE.
Safety has not been established and there are no data on the ejaculation-delaying effects in men without PE. Use with Recreational Drugs: Patients should be advised not to use Dapoxetine in combination with recreational drugs. Recreational drugs order priligy low cost with serotonergic activity eg, ketamine, methylenedioxymethamphetamine (MDMA) and lysergic acid diethylamide (LSD) may lead to potentially serious reactions if combined with Dapoxetine. These reactions include, but are not limited to, arrhythmia, hyperthermia and serotonin syndrome. Use of Dapoxetine with recreational drugs with sedative properties eg, narcotics and benzodiazepines may further increase somnolence and dizziness.
Ethanol: Combining alcohol with Dapoxetine may increase alcohol-related neurocognitive effects and may also enhance neurocardiogenic adverse events eg, syncope, thereby increasing the risk of accidental injury; therefore, patients should be advised to avoid alcohol while taking Dapoxetine. Possibly prodromal symptoms eg, nausea, dizziness/lightheadedness and diaphoresis were reported more frequently among patients treated with Dapoxetine compared to placebo. Orthostatic Hypotension: An orthostatic test should be performed before initiating therapy. In case of a history of documented or suspected orthostatic reaction, treatment with Dapoxetine should be avoided. Dapoxetine is not indicated for psychiatric disorders and should not be used in men with these disorders eg, schizophrenia, or in those suffering with co-morbid depression, as worsening of symptoms associated with depression cannot be excluded. Do not drink grapefruit juice within 24 hour prior to taking PRILIGY.
Common side effects include nausea; headache; dizziness; fainting or feeling dizzy upon standing; increased blood pressure; flushing; trembling; tingling or numbness; blurred vision, eye pain; ringing in ears; nasal congestion; dry mouth, vomiting, diarrhoea, constipation, abdominal pain, indigestion, intestinal gas, bloating ; excessive sweating; fatigue, sleepiness, yawning; difficulty paying attention, feeling irritable; erectile dysfunction (difficulty getting or keeping an erection); difficulty sleeping; anxiety, nervousness; decreased sexual desire; and abnormal dreams.
Dapoxetine selectively inhibits the reuptake of serotonin. It has limited direct action at other neurotransmitter sites including muscarinic receptors. PRILIGY 60 mg Film-coated Tablet manufactured by MENARINI INTERNATIONAL OPERATIONS LUXEMBOURG SA. Farmaco SA drug index information on PRILIGY Film-coated Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment. Saudi Arabian Japanese Pharmaceutical Co. Serious side effects requiring medical attention include fits (seizures); changes in your mood, thoughts of suicide or harming yourself; an allergic reaction; unusual bruising and bleeding. For more information, including what to do if you have any side effects, see Section This leaflet provides important information about using PRILIGY.