Although plasma levels of this drug at 24 hours post-dose are much lower than at peak concentration, it is unknown whether nitrates can be safely co-administered at this time point.
Concomitant use of organic nitrates in any form, either regularly or intermittently, because of the greater risk of hypotension Concomitant use of riociguat, a guanylate cyclase stimulator; PDE5 inhibitors, including this drug, may potentiate the hypotensive effects of riociguat.
Mild or Moderate Liver Dysfunction (Child-Pugh A or B): No adjustment recommended Severe Liver Dysfunction (Child-Pugh C): Data not available in this population. Initiate treatment with 25 mg orally once a day, as needed, about 1 hour prior to sexual activity Patients should be stable on alpha blocker therapy prior initiating treatment with this drug. Administration with CYP450 3A4 Inhibitors (e.g., ketoconazole, itraconazole, saquinavir) or Erythromycin: Consider a starting dose of 25 orally once a day, as needed, about 1 hour prior to sexual activity. Recommended dose: 25 mg orally, as needed, about 1 hour prior to sildenafil otc sexual activity Maximum dose: 25 mg orally within a 48 hour period Known hypersensitivity to either the active component or to any of the ingredients; hypersensitivity reactions have been reported, including rash and urticaria In patients who are using a guanylate cyclase (GC) stimulators, such as riociguat; phosphodiesterase type 5 inhibitors (PDE5), including this drug, may potentiate the hypotensive effects of GC stimulators. In patients who are using nitric oxide donors such as organic nitrates or organic nitrites in any form either regularly and/or intermittently; this drug has been shown to potentiate the hypotensive effects of nitrates based on its mechanism of action After patients have taken this drug for ED, it is unknown when nitrates, if necessary, can be safely administered. Known hypersensitivity to either the active component or to any of the ingredients of the tablet, injection, or oral suspension; hypersensitivity reactions have been reported, including anaphylactic reaction, anaphylactic shock, and anaphylactoid reaction Safety and efficacy have not been established in patients with ED younger than 18 years. Safety and efficacy have not been established in patients with PAH younger than 1 year. Due to high plasma protein binding and poor elimination in urine, removal via hemodialysis is unlikely.
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Tablets: Administer orally with or without food.
| Side Effect | Severity | Frequency | Comments |
|---|---|---|---|
| Headache | Mild to moderate | Common | Usually temporary |
| Flushing | Mild | Common | Due to vasodilation |
| Nasal Congestion | Mild | Less common | Temporary |
| Dizziness | Mild to moderate | Occasional | Be cautious when standing up |
Reconstitute product before oral administration, and shake well before use.
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BSc (Hons) MBBS MRCGP AFHEA MA (Hons) AFMCP “Efficacy and Safety of Sildenafil Citrate for Treatment of Erectile Dysfunction in a Population With Associated Organic Risk Factors.” Journal of Andrology (2013). “Efficacy and Safety of Sildenafil Citrate for Treatment of Erectile Dysfunction in a Population With Associated Organic Risk Factors.” Journal of Andrology (2013). Answer a few simple questions to get the treatment you need. Gramfu 500mg Tablet is an anti-toxin medication used to treat bacterial contaminations in your body. It is viable in contaminations of the lungs (e.g., pneumonia), ear, throat, nasal sinus, urinary plot, skin, delicate tissues, bones, and joints. An oral syringe is recommended for dose measurement (and delivery).
Maximum dose: 100 mg orally once a day Comments: This drug may be taken anywhere from 30 minutes to 4 hours before sexual activity. TABLETS (Revatio)/ORAL SUSPENSION (Revatio, Liqrev): Initial dose: 20 mg orally 3 times a day Maintenance dose: May titrate up to 80 mg orally 3 times a day, if required, based on symptoms and tolerability. Maximum dose: 80 mg orally 3 times a day IV: 10 mg IV bolus 3 times a day Comments: No adjustment for body weight is required for IV dosing. The 10 mg IV bolus dose is predicted to provide an equivalent pharmacological effect to that of 20 mg orally. Doses up to a maximum of 80 mg orally 3 times a day are supported by delayed clinical worsening with long-term use in clinical studies despite a lack of observed dose-response improvement in exercise ability in short-term clinical studies.
In adults 65 years or older, use caution with dose selection due to a higher incidence of compromised renal, cardiac, and/or hepatic function, and of concomitant disease or drug therapy. Use: For the treatment of PAH (WHO Group I) to improve exercise ability and delay clinical worsening TABLETS (Viagra) Initial dose: 25 mg orally once a day, as needed, about 1 hour prior to sexual activity Maintenance dose: May titrate up to 100 mg orally once a day, based on effectiveness and toleration. Maximum dose: 100 mg orally once a day Comments: This drug may be administered anywhere from 30 minutes to 4 hours before sexual activity. A reduced starting dose is recommended in older adults due to higher systemic exposure as compared to younger adults. TABLETS (Revatio)/ORAL SUSPENSION (Revatio) 1 to less than 18 years: Weight 20 kg or less: 10 mg orally 3 times a day Weight greater than 20 kg to 45 kg: 20 mg orally 3 times a day Weight greater than 45 kg: 20 mg orally 3 times a day; dose may be titrated up to a maximum of 40 mg orally 3 times a day, if required, based on symptoms and tolerability Use: For the treatment of pulmonary arterial hypertension (WHO Group I) to improve exercise ability and, in pediatric patients too young to perform standard exercise testing, pulmonary hemodynamics thought to underlie improvements in exercise ERECTILE DYSFUNCTION: Mild to Moderate Renal Dysfunction (CrCl 30 to 80 mL/min): No adjustment recommended Severe Renal Dysfunction (CrCl less than 30 mL/min): Consider a starting dose of 25 mg orally once a day, about 1 hour prior to sexual activity Mild, Moderate, or Severe Renal Dysfunction (CrCl 80 to less than 30 mL/min): No adjustment recommended ERECTILE DYSFUNCTION: Mild, Moderate, or Severe Liver Dysfunction (Child-Pugh A, B, or C): Consider a starting dose of 25 mg orally once a day, about 1 hour prior to sexual activity. Use within 60 days after reconstitution; discard any remainder after expiration. The liquid suspension is premixed and may contain flavoring.
Forestalling contaminations during surgery is sildenafil 60mg additionally utilized. Gramfu 500mg Tablet ought to be taken with food to keep away from an agitated stomach. You ought to take it routinely at uniformly dispersed stretches according to the timetable recommended by your PCP. Taking it simultaneously consistently will assist you with making sure to take it. The portion will rely upon what you are being treated for, yet you ought to constantly get done with a full course of this anti-microbial as endorsed by your primary care physician.
Try not to quit taking it until you have gotten done, in any event, when you feel far improved. Assuming you quit taking it early, a few microorganisms might get by and the disease might return. It won’t work for viral diseases like influenza or the normal virus. Utilizing any anti-toxin when you needn’t bother with it can make it less powerful for future contaminations. Applies to the following strengths: 10 mg/mL; 10 mg/12.5 mL; 20 mg; 25 mg; 50 mg; 100 mg; 75 mg TABLETS (Viagra) Initial dose: 50 mg orally once a day, as needed, about 1 hour prior to sexual activity Maintenance dose: May increase to 100 mg or decrease to 25 mg once a day, based on efficacy and tolerability. Shake well before oral administration and use a calibrated measuring device for accurate dosing.
The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. RLD / Brand Name: Viagra® Indication: Erectile Dysfunction Click to View Package Insert Click to View Material Data Safety Sheet Viagra® is a registered trademark of Pfizer Inc. RLD / Brand Name: Cialis® Indication: Benign Prostatic Hyperplasia and Erectile Dysfunction RLD / Brand Name: Cialis® Indication:Benign Prostatic Hyperplasia and Erectile Dysfunction Exports To: United States Of America Australia United Kingdom France Singapore United States Of America Australia United Kingdom France Singapore Established in the year of 2026, we “Rich Medex.” are Wholesaler and Exporter of an Erectile Dysfunction Medicine, Antiparasitic Drug, Testosterone Injection, etc. We direct all our activities to cater the expectations of customers by providing them excellent quality products as per their gratification.
Moreover, we follow moral business policies and crystal pure transparency in all our transactions to keep healthy relations with the customers.For our accomplishment story, we are grateful to our Miss. Ruchika Dayaldas Harwani, whose continual backing and direction have been useful to us for attaining exponential development in the current market. For our accomplishment story, we are grateful to our Miss. All content on this page has been medically reviewed by: Hassan Thwaini, Clinical Pharmacist and Copywriter, Master of Pharmacy (MPharm) on 30 March, 2026. Sildenafil is an effective treatment for erectile dysfunction. IV: Administer as an IV bolus injection; the supplied product is ready for use. Tablets/IV solution: Store at 20C to 25C (68F to 77F); excursions permitted to 15C to 30C (59F to 86F).
Oral suspension (liquid): Store at 20C to 25C (68F to 77F); excursions permitted to 15C to 30C (59F to 86F).
| Parameter | Value | Notes |
|---|---|---|
| Absorption | Rapid, within 30-60 minutes | Peak plasma levels occur at this time |
| Bioavailability | Approximately 40% | Due to first-pass metabolism |
| Half-life | 4-5 hours | Duration of effect |
| Metabolism | Liver via CYP3A4 enzyme | Variability based on liver function |
| Excretion | Mainly in feces, some in urine | Clearance mostly hepatic |
Oral suspension (powder): Store below 30C (86F) in the original package in order to protect from moisture.